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  • Designer Proteins

    Designer Proteins

    Image of the Week

    Scientists are custom-designing proteins, like these nanocages with many green fluorescent proteins attached

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Activity

    Students evaluate and discuss several statements about lactose intolerance and evolution before and after watching the film. Also available in Spanish.

  • Got Lactase? Blood Glucose Data Analysis

    Got Lactase? Blood Glucose Data Analysis

    Activity

    Students interpret the results of two different tests for lactase persistence.

  • The Chemical Structure of DNA

    The Chemical Structure of DNA

    Animation

    (2 min 44 sec) DNA's chemical properties can be harnessed for a variety of biotechnology applications.

  • Polymerase chain reaction (PCR)

    Polymerase chain reaction (PCR)

    Animation

    (54 sec) PCR is a standard laboratory technique that allows amplification of specific segments of DNA based on complementarity.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animation

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • AZT blocks reverse transcriptase

    AZT blocks reverse transcriptase

    Animation

    (1 min 46 sec) HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

  • Visualizing Gene-Expression Patterns

    Visualizing Gene-Expression Patterns

    Click & Learn

    Learn about the different ways scientists are able to detect when genes are being expressed in various tissues.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • Watson constructing base pair models

    Watson constructing base pair models

    Clip

    (1 min 42 sec) During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model.

  • Polymerase chain reaction

    Polymerase chain reaction

    Animation

    (1 min 28 sec) Polymerase chain reaction, or PCR, is a technique for making many copies of a specific DNA sequence. DNA is repeatedly heated and cooled in the presence of primers that bracket the desired sequence and of the enzyme Tac polymerase. In as few as 30 cycles, a billion copies of the target sequence can be made.

  • Damage to DNA leads to mutation

    Damage to DNA leads to mutation

    Animation

    (1 min 7 sec) Reactive molecules, such as free radicals, and solar ultraviolet radiation can lead to mutations in DNA. Most mutations are corrected, but in rare cases mutations can accumulate and cause diseases such as cancer.

  • Chargaff's Ratio

    Chargaff's Ratio

    Animation

    (49 sec) In 1950, Erwin Chargaff published a paper stating that in the DNA of any given species, the ratio of adenine to thymine is equal, as is the ratio of cytosine to guanine. This became known as Chargaff's ratio, and it was an important clue for solving the structure of DNA.

  • Building blocks of DNA

    Building blocks of DNA

    Animation

    (27 sec) Adenine (A), cytosine (C), guanine (G), and thymine (T) are the components of nucleic acid that make up DNA.

  • Life at the End of the Chromosome: Another RNA Machine

    Life at the End of the Chromosome: Another RNA Machine

    Lecture

    (58 min 20 sec) The chromosome ends, or telomeres, are necessary for DNA stability and replication.

  • How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA

    How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA

    Lecture

    (58 min 29 sec) Studies of RNA catalytic centers have revealed much about their structure and mode of action.

  • RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities

    RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities

    Lecture

    (58 min 22 sec) Discovery of RNA's catalytic activity led to unexpected spin-offs, including a new scenario for the origin of life.

  • Catalysis: Chemical and Biochemical

    Catalysis: Chemical and Biochemical

    Lecture

    (58 min 25 sec) Cellular enzymes are catalysts that tame reactions by accelerating them, lending specificity, and regulating their time and place.

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