In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health.
- 2006 Telly Awards; Silver
Scientists are unraveling the mechanisms that dictate how the brain and body regulate weight. In four presentations, Dr. Ronald M. Evans and Dr. Jeffrey M. Friedman discuss what the latest advances in genetic and molecular research tell us about why some people are hefty while others are lean. Understanding the biological systems that control body weight and metabolism, as well as these systems¿ environmental interactions, could lead scientists to treatments that curb obesity and treat its negative health consequences.
In This Series (5)
Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.
Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.