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PPAR-delta Activation in the Muscle Cell

More About PPAR-delta Activation in the Muscle Cell

The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat. 

PPAR-delta Activation in the Muscle Cell Background

PPAR-delta is one of a family of receptors that is related to the metabolism and storing of fat. Like PPAR-gamma, it also activates certain genes. However, PPAR-delta's activation signals the muscle cell to burn fat for energy. This led to the creation of a PPAR-delta-activated mouse, which can run significantly longer distances than regular mice, and which are more resistant to obesity.

From Lecture Three of the 2004 Holiday Lectures Series "The Science of Fat."

PPAR-delta Activation in the Muscle Cell Teaching Tips

The animations in this section have a wide variety of classroom applications. Use the tips below to get started but look for more specific teaching tips in the near future. Please tell us how you are using the animations in your classroom by sending e-mail to biointeractive@hhmi.org.

  1. Use the animations to make abstract scientific ideas visible and concrete.
  2. Explain important scientific principles through the animations. For example, the biological clocks animations can be used to demonstrate the fundamentals of transcription and translation.
  3. Make sure that students learn the material by repeating sections of the animations as often as you think necessary to reinforce underlying scientific principles. You can start, restart, and play back sections of the animations.
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  5. Incorporate the animations into Web-based learning modules that you create to supplement your classroom curricula.
  6. Encourage students to incorporate the animations into their own Web-based projects.

Resources

The 2004 Holiday Lectures Series "The Science of Fat"

PPAR-delta Activation in the Muscle Cell Credits

Director: Dennis Liu, Ph.D.

Scientific Direction: Ronald Evans, Ph.D.

Scientific Content: Satoshi Amagai, Ph.D.

Animator: Eric Keller

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