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The 2008 Holiday Lectures on Science What is mind? Can molecular biology help us understand mental function? Eric R. Kandel, M.D. and Thomas M. Jessell, Ph.D.of Columbia University will help us understand how the nervous system turns an idea into action—from the complex processing that takes place in the brain to the direct marching orders the spinal cord gives to the muscles. Modern neuroscience equates mind with the organ we call the brain, an astounding network more than 100 billion neurons connected in a vast complicated web. The presenters will help us puzzle out how the brain is organized and identify the seat of human memory. The question of understanding how the brain functions is rivaled by the question of how such a complex network of cells develops in the first place. Free on DVD Click here to view the lecture webcast on demand. Click here to view lecture summaries of the 2008 Holiday Lectures.
As part of the 2003 Holiday Lectures on Science, Dr. Huda Y. Zoghbi discusses how her patients have led her to a deeper understanding of the genetic and molecular bases of neurological disorders such as spinocerebellar ataxia and Rett syndrome. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures. Free on DVD Click here to view the lecture webcast on demand. Click here to view lecture summaries. Solutions to the poster questions can be found here. Lectures Three and Four The Strength of Families: Solving Rett Syndrome Lectures One and Two of the 2003 Holiday Lectures on Science are presented by Bert Voglestein, M.D., and can be found under the "Cancer" topic in the menu bar. The Puzzle of Rett Syndrome A disease can be a difficult puzzle to doctors and scientists until a breakthrough starts to bring a few of the pieces together. Imagine facing a three-year-old girl who cannot speak or pick up and hold things. She has abnormal breathing and she keeps moving her hands as though she is washing them. Her parents say she was a perfectly healthy baby until sometime after her first birthday. These are the telltale signs of Rett syndrome, a severe neurological disease that strikes mostly girls. But a diagnosis is difficult. There is no test for Rett syndrome, and many of its symptoms are similar to those of cerebral palsy and autism. Even with a proper diagnosis, no one knows what causes the disease or how to treat it. Read on... Polyglutamine Diseases: A Devastating Genetic Stutter Like a tiny time bomb, a genetic mutation can remain silent for many years before striking suddenly. Consider the mutation that causes the neurological disease spinocerebellar ataxia type 1 (SCA1). A person with this mutation in his or her DNA will usually be healthy until about 20 to 40 years of age and then will start having problems with balance and speech and perhaps lose muscle strength in the arms and legs. Read on...
Senses and Sensitivity Lecture Series In four talks, A. James Hudspeth, Ph.D., M.D., and Jeremy H. Nathans, Ph.D., M.D., discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing. Dr. Hudspeth is an HHMI investigator and head of the Laboratory of Sensory Neuroscience at The Rockefeller University. Dr. Nathans is an HHMI investigator and professor of molecular biology and genetics, of neuroscience, and of ophthalmology at The Johns Hopkins University School of Medicine. Click here to view the lecture webcast on demand. Sixth sense? Learn how some kinds of fish use electric fields for communication and navigation in this interactive demonstration.
The Virtual Neuroscience Lab Record electrical activities of individual neurons while you deliver mechanical stimulus to the attached skin. Inject fluorescent dyes into the neurons to visualize their morphology. Identify the neurons based on the morphology and the response to stimuli, comparing them to previously published results. Hearing and Seeing: Models for Thought Science is largely driven by curiosity and the desire to understand our place in the world. Neuroscience, focused on understanding how nervous systems work, is no exception. Diverse tools and methods are used to explore topics such as sensory perception, the control of movement, and even thinking. To watch the Holiday Lectures on Science: On-Demand Webcast Free on DVD Video podcast
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