A lesson that requires students to work through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria. These questions will probe students' understanding of Mendelian genetics, probability, pedigree analysis, and chi-square statistics.
Appropriate for: high school biology (all levels), introductory college biology.
This classroom activity uses the information presented in the short film The Making of the Fittest: Natural Selection in Humans to take students through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria resistance. The questions are divided into sections: Mendelian Genetics and Probability, Pedigrees, and Chi-Square Statistics. Within each section, the questions sequentially move from a basic level to a more advanced level in order to develop the skills of the students.
NGSS (April 2013)
HS-LS3-1, HS-LS3-2, HS-LS3-3, HS-LS4-2, HS-LS4-3, HS-LS4-4, LS1.A, LS2.A, LS3.A, LS3.B, LS4.B, LS4.C
Common Core (2010)
ELA-Literacy.RST.9-10.7, ELA-Literacy.RST.11-12.4, ELA-Literacy.RST.11-12.7, Math.Content.HSS-IC.A.1, Math.Content.HSS-MD.B.6
AP Biology (2012–13)
1.A.2, 3.A.3, 3.C.1, 3.C.2, 4.C.1
IB Biology (2009)
Topic 1, 4.1, 4.3, 5.4, 10.2