HomeBioInteractiveThe Making of the Fittest: Natural Selection in Humans


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Short Film
The Making of the Fittest: Natural Selection in Humans


In some parts of the world, there is an intimate connection between the infectious parasitic disease malaria and the genetic disease sickle cell anemia.

A keenly observant young man named Tony Allison, working in East Africa in the 1950s, first noticed the connection and assembled the pieces of the puzzle. His story stands as the first and one of the best understood examples of natural selection, where the selective agent, adaptive mutation, and molecule involved are known—and this is in humans to boot. The protection against malaria by the sickle-cell mutation shows how evolution does not necessarily result in the best solution imaginable but proceeds by whatever means are available.


  • Jackson Hole Science Media Awards; First Place (Best Short Program)
  • 2012 W3 Awards; Silver
  • 2012 Davey Awards; Silver

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This series of five short films features unforgettable examples of the evolutionary process in action.

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436 MB
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