From the 2003 Holiday Lectures — Learning From Patients: The Science of Medicine

Angiogenesis

A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.

1 minute 12 seconds

CML and Gleevec

Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.

41 seconds

Gleevec

Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

1 minute 3 seconds

Mismatch Repair

This animation illustrates how mistakes made during DNA replication are repaired.

1 minute 22 seconds

p53

A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

25 seconds

Using p53 to Fight Cancer

This animation demonstrates how cancerous cells could be destroyed using a modified virus.

1 minute 1 second

VEGF

This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

29 seconds