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Classroom Activities: The Birth and Death of Genes

Classroom Resource

The following classroom-ready resources complement The Making of the Fittest: The Birth and Death of Genes, which describes how scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and...

The Making of the Fittest: The Birth and Death of Genes

Short Film

Scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

Discussion with Students on The Day The Mesozoic Died Short Film

Lectures

Students discuss the short film after a screening at the 2012 Holiday Lectures on Science.

Test Your Knowledge of Microbes

Click & Learn

Take this quiz to see how well you understand some of the topics covered in the 1999 Holiday Lectures on infectious disease.

Sorting Seashells

Click & Learn

Explore principles of taxonomy by sorting seashells according to their morphological characteristics and constructing an evolutionary tree.

AZT blocks reverse transcriptase

Animation

HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

Coding sequences in DNA

Animation

Of the 3 billion letters in the human genome, only 1% directly code for proteins. Of the rest, about 25% make up genes and their regulatory elements. The functions of the remaining letters are still unclear.

Damage to DNA leads to mutation

Animation

Reactive molecules, such as free radicals, and solar ultraviolet radiation can lead to mutations in DNA. Most mutations are corrected, but in rare cases mutations can accumulate and cause diseases such as cancer.

Interview with JC Creveling

Interview

A graduate student in the Knoll lab, Ms. Creveling explains how she selects field sites, and what sparked her interest in geology.

Interview with Tom Laakso

Interview

A graduate student in the Schrag lab, Mr. Laakso uses computer modeling of Earth's atmosphere to help predict changes to come.

Paired DNA strands

Animation

DNA has a double helix structure. If untwisted, DNA looks like two parallel strands. Each strand has a linear sequence of A, C, G, and T. The precise order of the letters carries the coded instructions. One strand is a complementary image of the other: A always pairs with T, and C always pairs...

Genetic Switches

Click & Learn

Learn about how gene switches can control expression of genes in different tissues.

Interview with Bonnie Bassler

Interview

An interview with Dr. Bassler.

Interview with Michael McIntosh

Interview

An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.

Interview with Toto Olivera

Interview

An interview with Dr. Olivera.

Interview with Audra Pompeani

Interview

An interview with Dr. Audra Pompeani, a graduate student in Bonnie Bassler's lab.

Interview with Lee Swem

Interview

An interview with Dr. Lee Swem, a post-doctoral fellow in Bonnie Bassler's lab.

Polyp Removal

Video Clips

Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.

Interview with Harith Rajagopalan

Interview

An interview with Harith Rajagopalan, a scientist in Dr. Vogelstein's lab.

Interview with Dr. Bert Vogelstein

Interview

An interview with Dr. Vogelstein.

The Making of the Fittest: Natural Selection and Adaptation

Short Film

The rock pocket mouse is a living example of Darwin’s process of natural selection.

The Making of the Fittest: Natural Selection in Humans

Short Film

In some parts of the world, there is an intimate connection between the infectious parasitic disease malaria and the genetic disease sickle cell anemia.