Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.
Illustrates how studying one family's pedigree can reveal an entire history of passing on a genetic disorder such as SCA1.
The growth cone of a neuron avoids repellant molecules and navigates to innervate the appropriate muscle.
Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
Neurons in the cortical area 5 are active when a cat is straddling an obstacle.
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses.
Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.
A dramatic illustration of how hearing happens in the ear.
The fetal brain grows enormously during pregnancy, both in terms of its size and the number of neurons it has.
Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.
Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.
Illustrates how providing leptin to an obese mouse rapidly rewires its hypothalamus neurons.
Some cone snail toxins chemically hyperactivate neurons and immobilize prey, much like a Taser.
A touch to the Aplysia's siphon causes a gill withdrawal, a simple reflex for studying memory.
A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.
An interview with Dr. Kandel.
An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.
Clive Wearing has lost his ability to remember and lives in a perpetual state of having just awoken.
An interview with Dr. Laskaro Zagoraiou, a post-doctoral student in Thomas Jessell's lab.
What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
In this ten-minute Q&A session, Dr. Olivera answers questions on cone snail behavior, venoms, and biodiversity.