Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.
Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.
Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.
In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments...
Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.
Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.
HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.