The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.
View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of...
Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses.
A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.
Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.
Short-term memory relies on serotonin activating a protein kinase to modify existing synaptic strength.
Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.
Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.
Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.
A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.
A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.
A demonstration by Dr. Barbara Meyer of how a branched genetic pathway can be affected by mutations in different parts of the pathway.
An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.
A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.
Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.
Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.
A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.
Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.
What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.
In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.
How a nerve cell gets its identity, sends axons, and makes connections with other cells.
Understanding the neural circuits in the spinal cord that control movement.
The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice.
In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.
Dr. Hudspeth will begin by discussing how simple organisms—such as bacteria—have the capacity to detect and react to a stimulus.
Dr. Nathans will discuss how the visual process involves the detection of light by photo-receptors in the retina.
Dr. Hudspeth will explain the basis for the ear’s remarkable ability to detect sound through the hair cell, the sensory receptor found in the inner ear.
Dr. Nathans will complete the lecture series by clarifying what is known about the brain’s ability to process and integrate various elements of the visual system, such as color, motion, and depth.
Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.
Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.
The poster from the 2008 Holiday Lectures on Science, Making Your Mind: Molecules, Motion, and Memory. It illustrates the structure and function of a neuron, including how it transmits electrical and chemical signals.
(This poster is designed to printed at a maximum size of 29.5...
The immune system recognizes invaders in a complex way.
Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.
Genes associated with autism affect the structure and function of neuronal synapses.
This animated feature celebrates 17th-century citizen-scientist Antonie van Leeuwenhoek, whose discoveries of microbes changed our view of the biological world.
Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer.