A sample is put on a Virochip microarray, and results are compared to databases of all known viral sequences.
Delivering a single virus to a cell allows the virus to infect the cell, replicate, and give rise to many progeny viruses. These viruses can then infect many neighboring cells.
The geometric structures of viruses are beautiful and can be used, along with genomic information, to identify them.
A visual representation of the U.S. AIDS epidemic from 1981 to 1997. Each dot represents 30 cases.
In this animation, you can see how one S. typhimurium invades an epithelial cell of the intestinal tract, survives the intracellular defense mechanisms of the host cell, and multiplies.
Protease inhibitors prevent maturation of viral proteins inside HIV particles.
How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads.
Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.
Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.
Since the 1960s dengue fever has spread to many countries and total case numbers have exploded.
The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.
Infection begins when the dengue virus uses receptors on an immune cell's surface to gain entry and release its genome.
Watch this animation to see the molecular tricks that an infectious strain of Escherichia coli uses to infect your gut.
How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.
When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.
A mosquito becomes infected with malaria when it sucks the blood from an infected human. Once inside the mosquito, the parasites reproduce in the gut and accumulate in the salivary glands, ready to infect another human host with the next bite.
Adam Barrett describes his seven-drug antiretroviral regimen and the importance of adherence.
Adam Barrett, a nurse who is HIV positive, discusses his first symptoms and the challenges of adhering to a drug regimen.
The fight against dengue fever, and the mosquitoes that carry the virus, is being carried out by "brigadistas" in Managua's neighborhoods. Spanish with English subtitles.
Zinhle Thabethe describes how antiretroviral therapy has changed her life.
An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.
Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.
A live demonstration of how a rapid antibody-based HIV test works.
Several members of a Nicaraguan research team describe the impact of technology transfer.
An interview with Dr. DeRisi.
Catherine Gaynes, an HIV-positive patients, discusses her HIV diagnosis, how her family reacted, and avoiding HIV infection.
Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.
Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.
In the effort to eradicate dengue and mosquitoes, neighborhood leaders work with local conditions.
Dr. Beatrice Hahn discusses how HIV originated in Africa by cross-species transmission from chimpanzees to humans.
Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.
Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.
This microscope video shows how live Listeria move via actin filaments in an infected cell.
Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.
To prevent mosquitoes from spreading diseases, it's essential to understand their life cycle.
Reggaeton, a popular Latin music form, rallies against dengue.
Through the efforts of the Sustainable Sciences Institute, Nicaragua’s research capacity and disease-monitoring tools have improved dramatically.
Many infectious diseases affect people in Nicaragua, and identifying the pathogens is surprisingly difficult.
When parents die of AIDS, the orphans often go to live with a "gogo," the Zulu word for grandmother.
Doctors hope to encourage healers to direct their patients to clinics for TB and AIDS-related diseases.
A glimpse of the TB ward at a South African hospital, illustrating an illness associated with the AIDS epidemic.
A program designed to provide health care and housing to South Africans living in poverty.
Using soccer to teach children how to make important life choices and how to avoid HIV infection.
Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.
Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.
Adam Barrett remembers his symptoms of acute HIV infection.
Dr. Finlay, using his student audience, gives a live demonstration of how an antibiotic-resistant strain of tuberculosis managed to spread through the passengers on an airplane.
The Nicaraguan grassroots program teaches mosquito control methods to curb dengue fever epidemics.
Ben Vincent describes his summer work collecting mosquitoes for Dr. Marm Kilpatrick's research on the ecology and epidemiology of the West Nile virus.
Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.