In this animation, you can see how one S. typhimurium invades an epithelial cell of the intestinal tract, survives the intracellular defense mechanisms of the host cell, and multiplies.
Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.
Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.
Watch this animation to see the molecular tricks that an infectious strain of Escherichia coli uses to infect your gut.
When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.
A mosquito becomes infected with malaria when it sucks the blood from an infected human. Once inside the mosquito, the parasites reproduce in the gut and accumulate in the salivary glands, ready to infect another human host with the next bite.
Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.
Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.
Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.
Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.
This microscope video shows how live Listeria move via actin filaments in an infected cell.
Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.
Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.
Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.
Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.
Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.
In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics...
Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.
Dr. Finlay showcases three types of bacteria to illustrate how molecular biology is allowing researchers to probe the molecular workings of bacterial infections.
Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.
The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.
In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.
An activity that recreates zones of microbial activity in a glass column. To accompany the lecture series Changing Planet: Past, Present, Future.
A text transcript of the 1999 Holiday Lectures on Science, 2000 and Beyond: Confronting the Microbe Menace.