Dr. Zoghbi shows how a mouse that has been given the gene responsible for Rett syndrome exhibits some of the same neurological symptoms as human Rett patients.
Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs.
HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressive properties. It also allows two proteins which do not normally interact to bind together in the cell, which causes problems in the nutrient-sensing pathway.
Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.
A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.
One technique for discovering small molecules of biological relevance is to expose cultured cells to a variety of small molecules and look for changes in the cells' appearance, behavior or other measurable qualities.
Since the 1960s dengue fever has spread to many countries and total case numbers have exploded.
Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.
Sickle cell anemia is a genetic disease that affects hemoglobin.
Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.
A timeline illustrating the gradual effects of obesity on the body, including diabetes, atherosclerosis, and heart attack.
A 3-D animation that shows how plaques form in a blood vessel, leading to blockage and a heart attack.
How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.
When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.
Zinhle Thabethe describes how antiretroviral therapy has changed her life.
Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from ...
Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.
A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.
Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.
A live demonstration of how a rapid antibody-based HIV test works.
Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.
Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.
Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.
In the absence of proprioceptive feedback, some individuals can compensate by using visual feedback.