Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs.
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressive properties. It also allows two proteins which do not normally interact to bind together in the cell, which causes problems in the nutrient-sensing pathway.
Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.
A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.
One technique for discovering small molecules of biological relevance is to expose cultured cells to a variety of small molecules and look for changes in the cells' appearance, behavior or other measurable qualities.
Since the 1960s dengue fever has spread to many countries and total case numbers have exploded.
Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.
Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.
A timeline illustrating the gradual effects of obesity on the body, including diabetes, atherosclerosis, and heart attack.
A 3-D animation that shows how plaques form in a blood vessel, leading to blockage and a heart attack.
When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.
Zinhle Thabethe describes how antiretroviral therapy has changed her life.
Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.
A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.
Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.
A live demonstration of how a rapid antibody-based HIV test works.
Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.
Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.
Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.
In the absence of proprioceptive feedback, some individuals can compensate by using visual feedback.
How a South African hospital is coping with the HIV/AIDS epidemic and its many related healthcare issues.
Using soccer to teach children how to make important life choices and how to avoid HIV infection.
Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.
Dr. Huda Zoghbi interviews Milan Cloud, a patient who has inherited the neurological disorder spinocerebellar ataxia 1, or SCA1.
Why has it been so hard to develop a vaccine against HIV? How are new medicines revolutionizing AIDS treatment? Can AIDS be cured?