A sample is put on a Virochip microarray, and results are compared to databases of all known viral sequences.
The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA...
In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their...
A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.
Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.
Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.
New technologies like the Virochip harness DNA's properties to identify and fight new viruses.
The SARS epidemic was successfully halted by a global research effort to identify a new virus.
Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
Learn the principles of how DNA is sequenced and assembled into whole genomes using the Sanger method, shotgun sequencing, or ultra-deep sequencing.
Answer interactive questions to explore the logic of the Virochip microarray design, particularly how evolutionary relationships can be used to detect new viruses.
A new technique tracks thousands of cells in the fruit fly (Drosophila) embryo during development.
Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.
This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are guided to sort the lizard species by appearance, then generate a phylogenetic tree using the lizards’ DNA sequences to evaluate whether species that appear similar are closely...
Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.
Learn about the science and techniques used to identify different types of bacteria based on their DNA sequences