Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.
Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
Some cone snail toxins chemically hyperactivate neurons and immobilize prey, much like a Taser.
A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.
An interview with Dr. Bassler.
The bobtail squid swims during the night to hunt. During the day, it burrows to hide from predators.
Dr. Olivera demonstrates a live specimen of Conus striatus.
This species of cone snail immobilizes its prey in a split second with lightning-strike cabal toxins.
A fish-hunting cone snail strikes its prey with a venomous harpoon, causes paralysis, and eats it.
Larger cone snails produce more venom and are more dangerous to human beings in an accidental stinging.
A worm-hunting cone snail species feeds on fireworms, and is unaffected by the prey's sharp bristles.
A species of fish-hunting cone snail quickly immobilizes its prey and swallows it.
A snail-hunting species of cone snail stings its prey repeatedly, inducing the prey to thrash about.
Unlike a hook-and-line type fish-hunter, a net-hunting cone snail lures its prey into its wide mouth.
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.
A mini-documentary illustrating the importance of the ocean to the Filipino way of life, and how that close connection helps biodiversity research.
An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.
An interview with Dr. Olivera.
The Philippines archipelago is rich in marine biodiversity, including venomous octopus and venomous snails.
An interview with Dr. Audra Pompeani, a graduate student in Bonnie Bassler's lab.
Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.
Robotic equipment makes it possible to screen massive chemical libraries in just a matter of days.
An interview with Dr. Lee Swem, a post-doctoral fellow in Bonnie Bassler's lab.