Somatic cell nuclear transfer (SCNT) is a technique for cloning. The nucleus is removed from a healthy egg. This egg becomes the host for a nucleus that is transplanted from another cell, such as a skin cell. The resulting embryo can be used to generate embryonic stem cells with a genetic match...
Urodele amphibians—newts and salamanders—are able to regenerate fully functional limbs in response to amputation. Cells in and near the limb stump dedifferentiate to form a mass of stemlike cells that can produce all the specialized tissues of the limb, such as muscle, nerves, and blood vessels...
The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.
Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development.
As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become...
Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during...
Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.
Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells.
Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another.
Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.
An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.
The role of stem cells in regeneration, and ongoing research to improve mammalian regeneration potency.
In cloning, a cell's genetic machinery is reprogrammed. Can we similarly coax stem cells to become specific cell types?
Finding factors to reverse age-related loss of cell maintenance, and some examples of stem cell therapies.
A discussion on policies and ethical issues associated with stem cell research.
An overview and comparison of different regenerative capabilities in many different organisms.
An exploration of current and future therapies.
To accompany the lecture series Potent Biology: Stem Cells, Cloning, and Regeneration.
A text transcript of the 2006 Holiday Lectures on Science, Potent Biology: Stem Cells, Cloning, and Regeneration.
A chapter list to accompany the DVD.
The developing brain needs a constant source of new cells as it builds the circuits that will control behavior.
Most of the neurons of the cerebral cortex arise from progenitor cells that undergo repeated cell division.
The poster from the 2006 Holiday Lectures on Science, Potent Biology: Stem Cells, Cloning, and Regeneration, illustrates the role of stem cells during human embryonic development.
Zebrafish blood is generated from stem cells located in the tail region of fish embryos and later from stem cells located in the kidney of the adult fish.
A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.