View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of...
Protease inhibitors prevent maturation of viral proteins inside HIV particles.
How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads.
Short-term memory relies on serotonin activating a protein kinase to modify existing synaptic strength.
Adam Barrett describes his seven-drug antiretroviral regimen and the importance of adherence.
Adam Barrett, a nurse who is HIV positive, discusses his first symptoms and the challenges of adhering to a drug regimen.
Video microscopy of a cytotoxic T lymphocyte in action.
An interview with Katie Walter, an undergraduate who discusses what it's like to be in a lab doing scientific research.
Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.
Understanding the immune response is essential to developing safe vaccines for dengue and other diseases.
Why has it been so hard to develop a vaccine against HIV? How are new medicines revolutionizing AIDS treatment? Can AIDS be cured?
The genesis of AIDS, identifying HIV as the virus that causes AIDS, and the modern global epidemic.
The HIV life cycle, and how the virus destroys the immune system's ability to respond to infection.
The search for an effective HIV vaccine, and advances in genomics that may lead to a breakthrough.
This virtual lab teaches the procedures of performing an ELISA test to determine whether a particular antibody is present in a patient's blood sample.
An overview of the immune system, concentrating on the roles played by B and T lymphocytes, and the antigen-presentation system.
This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework.
The poster from the 2007 Holiday Lectures on Science, AIDS: Evolution of an Epidemic. It shows each stage of the HIV life cycle and highlights points in the cycle that have been targeted by anti-retroviral drugs.
A wide overview of the immune system, presented by HHMI investigators John W. Kappler, PhD, and Philippa Marrack, PhD
The human body has at least a trillion ways of recognizing that something foreign has invaded.
The immune system recognizes invaders in a complex way.
Normally the trillions of lymphocytes in the human body do not attack their host.
Some organisms have evolved ways of evading or subverting the body's defenses.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.
The measles virus can spread easily among people who have no immunity against it, as the current outbreak shows.