The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.
The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.
Comparison of the change in BMI for a given height and varying weights.
An overview of how dietary fat gets digested, packaged, and sent to various tissues for storage or energy.
A timeline illustrating the gradual effects of obesity on the body, including diabetes, atherosclerosis, and heart attack.
A 3-D animation that shows how plaques form in a blood vessel, leading to blockage and a heart attack.
A 3-D animation that shows the location of the hypothalamus in a mouse's brain.
Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.
Illustrates how providing leptin to an obese mouse rapidly rewires its hypothalamus neurons.
An interview with Grant Barish, a scientist in Dr. Evans's lab.
An interview with Dr. Evans.
An interview with Dr. Friedman.
An interview with Shirly Pinto, a scientist in Dr. Friedman's lab.
In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments...
Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.
Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.
A Q&A session on obesity and related issues, with the lecturers and students attending the Holiday Lectures on Science.
There is no way to directly measure how much fat a living person has. Learn about the various methods used by researchers and fitness advisors to estimate a person’s body fat.
This slide show delves into the various molecular shapes that fat can take.
This slide show explores some of the ways the body processes fat, including digestion, transport, conversion, and energy extraction.
HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.
Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.
Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.