The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.
Somatic cell nuclear transfer (SCNT) is a technique for cloning. The nucleus is removed from a healthy egg. This egg becomes the host for a nucleus that is transplanted from another cell, such as a skin cell. The resulting embryo can be used to generate embryonic stem cells with a genetic match...
Urodele amphibians—newts and salamanders—are able to regenerate fully functional limbs in response to amputation. Cells in and near the limb stump dedifferentiate to form a mass of stemlike cells that can produce all the specialized tissues of the limb, such as muscle, nerves, and blood vessels...
The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.
Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development.
As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become...
Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during...
Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.
An interview with Amy Greenwood and Alice Chen, two scientists in Dr. Melton's lab.
Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.
Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells.
An interview with Dr. Jose Gonzales, Manager of the Laboratory Animal Resources and Knockout Mouse Facility at EMBL in Monterotondo Italy.
An interview with Dr. Melton.
An interview with Olivier Mirabeau, a scientist in Dr. Rosenthal's lab.
An interview with Dr Mumna Al Banchaabouchi, researcher in the Mouse Phenotyping Core at EMBL in Monterotondo Italy.
A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.
An interview with Dr. Rosenthal.
Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another.
Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.
Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.
An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.
The role of stem cells in regeneration, and ongoing research to improve mammalian regeneration potency.
In cloning, a cell's genetic machinery is reprogrammed. Can we similarly coax stem cells to become specific cell types?
Finding factors to reverse age-related loss of cell maintenance, and some examples of stem cell therapies.
A discussion on policies and ethical issues associated with stem cell research.