After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.
The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA...
In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their...
Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.
Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.
Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.
Genetic evidence shows that humans evolved in Africa and continue to evolve.
New technologies like the Virochip harness DNA's properties to identify and fight new viruses.
The SARS epidemic was successfully halted by a global research effort to identify a new virus.
Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
A wide-ranging 45-minute discussion between Dr. Eric Lander, Dr. Stuart Schreiber, and four Washington DC-area high school teachers.
DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.
All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.
A text transcript of the 2002 Holiday Lectures on Science, Scanning Life's Matrix: Genes, Proteins, and Small Molecules.
In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.
A brochure from the 2013 Holiday Lectures on Science.
Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.
Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer.
The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia.
Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.
Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.
Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.
A student discussion with the lecturers of the 2013 Holiday Lectures on Science.
Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.
Dr. Walsh recalls his childhood as one of eight siblings, discovering science in college, and the role of genomics in studying autism.
Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.
Ms. Yang describes what it was like growing up in a family filled with medical doctors, discusses her MD-PhD program, and provides advice to high school students interested in science.
Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.
Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.
In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.
HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.