In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.
A brochure from the 2013 Holiday Lectures on Science.
The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.
Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.
Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer.
The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia.
Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.
Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.
Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.
Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.
A student discussion with the lecturers of the 2013 Holiday Lectures on Science.
Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.
Dr. Walsh recalls his childhood as one of eight siblings, discovering science in college, and the role of genomics in studying autism.
Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.
Ms. Balbas discusses her early interest in medicine, her path to becoming a researcher, and her best day in the lab.
Ms. Diaz discusses her family's emphasis on academics, how she discovered neuroscience, and describes a typical day in the lab.
Ms. Yang describes what it was like growing up in a family filled with medical doctors, discusses her MD-PhD program, and provides advice to high school students interested in science.
Most of the neurons of the cerebral cortex arise from progenitor cells that undergo repeated cell division.
Genes associated with autism affect the structure and function of neuronal synapses.
Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer.
A new technique for making the brain transparent provides extremely detailed views of groups of neurons.
Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.
Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.
Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.
Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.
A 3D model of BCR-ABL, an unregulated kinase that causes cancer.
A 3D model of adenosine triphosphate, or ATP.
A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.
A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.
In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer.
These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers.
In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.
This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.
Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer.