A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.
Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.
Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.
Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.
As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge...
Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.
The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.
A text transcript of the 2003 Holiday Lectures on Science, Learning From Patients: The Science of Medicine.
A chapter list to accompany the DVD.
In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.
A brochure from the 2013 Holiday Lectures on Science.
Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.