Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.
Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.
This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes.