Somatic cell nuclear transfer (SCNT) is a technique for cloning. The nucleus is removed from a healthy egg. This egg becomes the host for a nucleus that is transplanted from another cell, such as a skin cell. The resulting embryo can be used to generate embryonic stem cells with a genetic match...
The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.
Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development.
As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become...
Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during...
A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.
Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.
An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.
In cloning, a cell's genetic machinery is reprogrammed. Can we similarly coax stem cells to become specific cell types?
To accompany the lecture series Potent Biology: Stem Cells, Cloning, and Regeneration.
The poster from the 2006 Holiday Lectures on Science, Potent Biology: Stem Cells, Cloning, and Regeneration, illustrates the role of stem cells during human embryonic development.