After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
A text transcript of the 2002 Holiday Lectures on Science, Scanning Life's Matrix: Genes, Proteins, and Small Molecules.