In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.
A brochure from the 2013 Holiday Lectures on Science.
The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.
Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer.
The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia.
Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.
Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.
Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.
A student discussion with the lecturers of the 2013 Holiday Lectures on Science.
Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.
Ms. Balbas discusses her early interest in medicine, her path to becoming a researcher, and her best day in the lab.
Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer.
Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.
A 3D model of BCR-ABL, an unregulated kinase that causes cancer.
A 3D model of adenosine triphosphate, or ATP.
A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.
A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.
In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer.
These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers.
This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.
Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer.