After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.
In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their...
Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.
New technologies like the Virochip harness DNA's properties to identify and fight new viruses.
The SARS epidemic was successfully halted by a global research effort to identify a new virus.
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.
Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.