A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.
The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Dr. Page explains how successive inversions and deletions of the Y chromosome during mammalian evolution have reduced it to its present form—small and sparsely populated with genes.
Although tiny in size, the fruit fly has had a major impact on our understanding of circadian rhythms.
Dr. Rosbash discloses how scientists have persuaded Mother Nature to reveal the inner workings of the fruit fly's biological clock.
Dr. Takahashi describes the powerful strategies that he and others have harnessed for understanding biological clocks in mammals.
Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.