Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.
The role of stem cells in regeneration, and ongoing research to improve mammalian regeneration potency.
Finding factors to reverse age-related loss of cell maintenance, and some examples of stem cell therapies.
The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.
Urodele amphibians—newts and salamanders—are able to regenerate fully functional limbs in response to amputation. Cells in and near the limb stump dedifferentiate to form a mass of stemlike cells that can produce all the specialized tissues of the limb, such as muscle, nerves, and blood vessels.
This activity uses the planaria's property for regeneration and compares how long it takes for planaria cut in different places to regenerate a head.
A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.
Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.