What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
How a nerve cell gets its identity, sends axons, and makes connections with other cells.
Understanding the neural circuits in the spinal cord that control movement.
The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice.
In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.
Dr. Hudspeth will begin by discussing how simple organisms—such as bacteria—have the capacity to detect and react to a stimulus.
Dr. Nathans will discuss how the visual process involves the detection of light by photo-receptors in the retina.
Dr. Hudspeth will explain the basis for the ear’s remarkable ability to detect sound through the hair cell, the sensory receptor found in the inner ear.
Dr. Nathans will complete the lecture series by clarifying what is known about the brain’s ability to process and integrate various elements of the visual system, such as color, motion, and depth.
Finding factors to reverse age-related loss of cell maintenance, and some examples of stem cell therapies.
In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments...
Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.
Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.
A Q&A session on obesity and related issues, with the lecturers and students attending the Holiday Lectures on Science.
In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.
The heart acts as a dual pump, sending oxygen-depleted blood to the lungs to be reinvigorated and pumping oxygen-rich blood to vital organs throughout the body.
Molecular genetic approaches have identified genes that, when mutated, cause either increased or decreased blood pressure.
Scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.
The following classroom-ready resources complement The Making of the Fittest: The Birth and Death of Genes, which describes how scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as...
A simple activity that investigates the importance of antifreeze proteins to icefish survival.
A simple demonstration that uses readily-available materials to simulate how blood pumps through the circulatory system of icefish and other fish.