Microarray technology is useful for screening many small molecules at once. Automated devices have made it possible for thousands of different small molecules to be printed as an array of spots on a glass slide. A single type of protein which has been tagged with a fluorescent marker can then be...
The hypothetical relationship of chemical space and biological space is plotted on a three-dimensional graph, giving a glimpse of the future direction of research at the intersections of various disciplines.
In diversity-oriented synthesis, many combinations of chemical building blocks undergo relatively few reaction steps to form a vast variety of different molecules. In this example, 45 x 45 x 45 combinations yield more than 88,000 novel molecules.
The small molecule 'furrowstatin' exemplifies the power of using small molecules to investigate life's processes. When applied to dividing cells, the furrowstatin halts cell division.
Without an appropriate catalyst some chemical reactions would be so slow as to appear not to occur at all on the human timescale. However, when catalyzed, these reactions can be very dramatic.
Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS...
Dr. Cech uses a penny and a beaker of acetone to illustrate how a catalyst works.
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
In four lectures, Nobel laureate Thomas R. Cech, PhD, discusses the ability of RNA to act as more than just an intermediary between DNA and proteins.
Cellular enzymes are catalysts that tame reactions by accelerating them, lending specificity, and regulating their time and place.
Discovery of RNA's catalytic activity led to unexpected spin-offs, including a new scenario for the origin of life.
Studies of RNA catalytic centers have revealed much about their structure and mode of action.
The chromosome ends, or telomeres, are necessary for DNA stability and replication.
Small molecules are chemicals that can interact with proteins to affect their functions. Learn about the structure and biological functions of various small molecules like sugar and caffeine.
This slide show delves into the various molecular shapes that fat can take.
An activity that recreates zones of microbial activity in a glass column. To accompany the lecture series Changing Planet: Past, Present, Future.
A lesson in which students analyze the chemical data that led researchers to conclude that the K-T boundary layer contained an extraordinary concentration of iridium.
A worksheet in which students calculate how much iridium was released, and eventually deposited all over the Earth, by the impact of the asteroid that caused the K-T extinction.
To accompany the lecture series Scanning Life's Matrix: Genes, Proteins, and Small Molecules.
Earth has been both cooler and warmer in the past, but the change is usually gradual. The current rate of carbon dioxide increase is unprecedented in human history, and solutions to mitigate its effect on global warming are challenging to implement.
Explore the changes in oxygen levels throughout Earth’s history and discover their impact on life.
Pushing the limits of light microscopy to the nanoscale, new technology allows visualization of single proteins in cells.
This activity guides students through building a conceptual model of how carbon dioxide affects Earth's climate