Delivering a single virus to a cell allows the virus to infect the cell, replicate, and give rise to many progeny viruses. These viruses can then infect many neighboring cells.
In this animation, you can see how one S. typhimurium invades an epithelial cell of the intestinal tract, survives the intracellular defense mechanisms of the host cell, and multiplies.
When two different strains of influenza infect a single cell, their genetic material can mix freely, resulting in a new third strain of influenza.
Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.
Watch this animation to see the molecular tricks that an infectious strain of Escherichia coli uses to infect your gut.
Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.
Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.
An interview with Dr. Finlay.
An interview with Dr. Ganem.
Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.
Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.
This microscope video shows how live Listeria move via actin filaments in an infected cell.
Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.
Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.
Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.
Dr. Finlay, using his student audience, gives a live demonstration of how an antibiotic-resistant strain of tuberculosis managed to spread through the passengers on an airplane.
Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.
In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics...
Dr. Donald Ganem describes how epidemiologists, physicians, and microbiologists work together to identify and study pathogens.
Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.
Dr. Finlay showcases three types of bacteria to illustrate how molecular biology is allowing researchers to probe the molecular workings of bacterial infections.
Dr. Ganem analyses the complex causes of epidemics—how changes in the environment and in human social behavior can give rise to new infectious diseases.
This virtual lab will familiarize you with the science and techniques used to identify different types of bacteria based on their DNA sequences.
Take this quiz to see how well you understand some of the topics covered in the 1999 Holiday Lectures on infectious disease.
A text transcript of the 1999 Holiday Lectures on Science, 2000 and Beyond: Confronting the Microbe Menace.