This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.
This animation demonstrates how cancerous cells could be destroyed using a modified virus.
Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs.
Illustrates how studying one family's pedigree can reveal an entire history of passing on a genetic disorder such as SCA1.
This animation illustrates how mistakes made during DNA replication are repaired.
A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.
This animation shows how the protein MECP2, in conjuction with another protein complex, can act as an "on-off' switch for gene expression.
A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs.
A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.
Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.
An interview with Dr. Zoghbi.
Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.
An interview with Jennifer Gatchel, a scientist in Dr. Zoghbi's lab.
An interview with Harith Rajagopalan, a scientist in Dr. Vogelstein's lab.
Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.
Dr. Huda Zoghbi interviews Milan Cloud, a patient who has inherited the neurological disorder spinocerebellar ataxia 1, or SCA1.
What do humans, flies, and worms have in common? More than you might think. See how transgenic organisms are engineered, and how they enable researchers to study genetic diseases.
An interview with Dr. Vogelstein.
As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge...
Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.
The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.
Mutations in key genes can lay waste to the nervous system. By studying large families predisposed to developing these genetic disorders, scientists can identify the responsible altered gene.
Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.
Genetic research benefits health, but also raises thorny ethical issues.
Learn about what p53 does, and how interfering with its function can lead to cancer.