What is mind? Can molecular biology help us understand mental function?
The history of localization of function in the brain, and research that led to the understanding of localization of memory.
How a nerve cell gets its identity, sends axons, and makes connections with other cells.
Understanding the neural circuits in the spinal cord that control movement.
The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice.
The lecturers, joined by Dr. Kay Jamison of the Johns Hopkins University School of Medicine and Dr. Gerald Fischbach of the Simons Foundation, answer questions concerning autism, manic depression, and other mental illnesses.
To accompany the lecture series Making Your Mind: Molecules, Motion, and Memory.
The fetal brain grows enormously during pregnancy, both in terms of its size and the number of neurons it has.
Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.
Short-term memory relies on serotonin activating a protein kinase to modify existing synaptic strength.
Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.
Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.
Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses.
Neurons in the cortical area 5 are active when a cat is straddling an obstacle.
The growth cone of a neuron avoids repellant molecules and navigates to innervate the appropriate muscle.
Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.
The poster from the 2008 Holiday Lectures on Science, Making Your Mind: Molecules, Motion, and Memory. It illustrates the structure and function of a neuron, including how it transmits electrical and chemical signals.
(This poster is designed to printed at a maximum size of 29.5...
Measuring neuronal activity, generating action potentials, and recording the firing of individual neurons.
Different gaits employed by animals and how the nervous system is able to switch between them.
An interview with Dr. Adam Hantman, a post-doctoral student in Thomas Jessell's lab.
An interview with Dr. Kandel.
An interview with Dr. Laskaro Zagoraiou, a post-doctoral student in Thomas Jessell's lab.
An interview with Dr. Jessell.
An interview with Priya Rajasethupathy, an MD/PhD student in Eric Kandel's lab.
An interview with Tessa Hirschfeld-Stoler, a lab technician in Eric Kandel's lab.