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Showing 1 - 23 of 23 results
Click & Learn
There is no way to directly measure how much fat a living person has. Learn about the various methods used by researchers and fitness advisors to estimate a person’s body fat.
Click & Learn
This slide show delves into the various molecular shapes that fat can take.
Click & Learn
This slide show explores some of the ways the body processes fat, including digestion, transport, conversion, and energy extraction.
Classroom Resource
A text transcript of the 2004 Holiday Lectures on Science, Science of Fat.
Video Clips
Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.
Video Clips
Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.
Lectures
Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.
Lectures
Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.
Lectures
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Lectures
Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.
Lectures
A Q&A session on obesity and related issues, with the lecturers and students attending the Holiday Lectures on Science.
Series
In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments...
Animation
Comparison of the change in BMI for a given height and varying weights.
Animation
The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.
Animation
The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.
Animation
An overview of how dietary fat gets digested, packaged, and sent to various tissues for storage or energy.
Animation
A timeline illustrating the gradual effects of obesity on the body, including diabetes, atherosclerosis, and heart attack.
Animation
A 3-D animation that shows how plaques form in a blood vessel, leading to blockage and a heart attack.
Animation
A 3-D animation that shows the location of the hypothalamus in a mouse's brain.
Animation
Illustrates how providing leptin to an obese mouse rapidly rewires its hypothalamus neurons.
Animation
Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.
