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Classroom Resource
To accompany the lecture series Evolution: Constant Change and Common Threads.
Classroom Resource
Topics include: Gene expression, RNA structure and function, transcription, RNA processing, translation, and post-translational events.
Classroom Resource
Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.
Classroom Resource
The following classroom-ready resources complement Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in drastically different environments. Scientists have studied both living and fossil stickleback populations,...
Click & Learn
Learn about how gene switches can control expression of genes in different tissues.
Lectures
Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.
Lectures
Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
Lectures
The genetic mechanisms by which evolution occurs, and an overview of the evidence for evolutionary theory.
Lectures
How and why butterflies and fruit flies got their spots, and the fossil record for human evolution.
Lectures
Genetic evidence shows that humans evolved in Africa and continue to evolve.
Series
Where and when did humans arise? What distinguishes us from other species? Did our distant ancestors look and behave like us?
Series
How has the amazing diversity of plants and animals evolved? What can fossils, butterflies, and stickleback fish tell us about the deep common ancestry of all living forms?
Lectures
Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.
Lectures
Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.
Animation
General transcription factors, activators, and repressors interact to regulate the transcription of eukaryotic DNA into RNA.
Animation
Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.
Animation
In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch...
Animation
The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.
Animation
This animation shows how the protein MECP2, in conjuction with another protein complex, can act as an "on-off' switch for gene expression.
Animation
This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes.
Animation
This animation shows the molecular interactions involved in the negative feedback loop responsible for circadian rhythms in mammals.
Click & Learn
Lactase persistence results from a mutation that changes how transcription factors interact, thereby affecting gene expression.
Click & Learn
RNA interference is an exciting new research tool for shutting down genes. It could also yield new medical treatments.
Short Film
After the end of the last ice age 10,000 years ago, populations of marine stickleback fish became stranded in freshwater lakes dotted throughout the Northern Hemisphere in places of natural beauty like Alaska and British Columbia. These remarkable little fish have adapted and thrive, living...
Animation
Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.
