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    Classroom Activities: Gene Switches
    Classroom Resource
    To accompany the lecture series Evolution: Constant Change and Common Threads.
    Teacher Guide: AP Biology
    Classroom Resource
    This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 
    Teacher Guide: Biotechnology
    Classroom Resource
    Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarray. This guide includes multiple classroom-ready worksheets to accompany HHMI’s virtual labs.
    Teacher Guide: Gene Expression
    Classroom Resource
    Topics include: Gene expression, RNA structure and function, transcription, RNA processing, translation, and post-translational events.
    Teacher Guide: Gene Regulation
    Classroom Resource
    Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.
    Classroom Activities: Evolving Switches, Evolving Bodies
    Classroom Resource
    The following classroom-ready resources complement Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in drastically different environments. Scientists have studied both living and fossil stickleback populations,...
    Genetic Switches
    Click & Learn
    Learn about how gene switches can control expression of genes in different tissues.
    Bacterial Quorum Sensing
    Click & Learn
    Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.
    Visualizing Gene-Expression Patterns
    Click & Learn
    Learn about the different ways scientists are able to detect when genes are being expressed in various tissues.
    How to Analyze DNA Microarray Data
    Click & Learn
    DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.
    Molecular Genetics of Color Mutations in Rock Pocket Mice
    Classroom Resource
    A lesson that requires students to transcribe and translate portions of the wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film.
    Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
    Classroom Resource
    A hands-on activity in which students interpret molecular diagrams and build physical models of eukaryotic gene regulation.
    The Central Dogma Song
    Video Clips
    “The Assemblers” (Peter Skewes-Cox and Dr. Graham Ruby) sing about DNA and proteins.
    Balancing the Fat Equation
    Lectures
    Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.
    Understanding Embryonic Stem Cells
    Lectures
    An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.
    Adult Stem Cells and Regeneration
    Lectures
    The role of stem cells in regeneration, and ongoing research to improve mammalian regeneration potency.
    Building Brains: The Molecular Logic of Neural Circuits
    Lectures
    How a nerve cell gets its identity, sends axons, and makes connections with other cells.
    Hermaphrodites: The Safer Sex
    Lectures
    Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.
    Sex and Death: Too Much of a Good Thing
    Lectures
    Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.
    Unwinding Clock Genetics
    Lectures
    Although tiny in size, the fruit fly has had a major impact on our understanding of circadian rhythms.
    PERfect TIMing
    Lectures
    Dr. Rosbash discloses how scientists have persuaded Mother Nature to reveal the inner workings of the fruit fly's biological clock.
    The Mammalian Timekeeper
    Lectures
    Dr. Takahashi describes the powerful strategies that he and others have harnessed for understanding biological clocks in mammals.
    How Immune Cells Create Trillions of Receptors from a Few Hundred Parts
    Lectures
    The human body has at least a trillion ways of recognizing that something foreign has invaded.
    Clockwork Genes: Discoveries in Biological Time
    Series
    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.
    mRNA splicing
    Animation
    Once a gene has been transcribed into messenger RNA (mRNA), it is edited in a process called splicing. Noncoding regions called introns are removed, leaving protein-coding regions called exons.

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