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    Poster: How Neurons Work
    Classroom Resource
    The poster from the 2008 Holiday Lectures on Science, Making Your Mind: Molecules, Motion, and Memory. It illustrates the structure and function of a neuron, including how it transmits electrical and chemical signals.
    Symbiotic Bioluminescence
    Click & Learn
    Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.
    Bacterial Quorum Sensing
    Click & Learn
    Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.
    Interview with Silvia Caballero
    Interview
    An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.
    Dosage Compensation in C. elegans
    Video Clips
    A demonstration by Dr. Barbara Meyer of how a branched genetic pathway can be affected by mutations in different parts of the pathway.
    Demo: Electrical measurement of muscle activity
    Video Clips
    A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.
    Contact repulsion of a growth cone
    Video Clips
    A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.
    Sensory Transduction: Getting the Message
    Lectures
    Dr. Hudspeth will begin by discussing how simple organisms—such as bacteria—have the capacity to detect and react to a stimulus.
    The Science of Sight: Getting the Picture
    Lectures
    Dr. Nathans will discuss how the visual process involves the detection of light by photo-receptors in the retina.
    The Science of Sound: How Hearing Happens
    Lectures
    Dr. Hudspeth will explain the basis for the ear’s remarkable ability to detect sound through the hair cell, the sensory receptor found in the inner ear.
    Neural Processing: Making Sense of Sensory Information
    Lectures
    Dr. Nathans will complete the lecture series by clarifying what is known about the brain’s ability to process and integrate various elements of the visual system, such as color, motion, and depth.
    Building Brains: The Molecular Logic of Neural Circuits
    Lectures
    How a nerve cell gets its identity, sends axons, and makes connections with other cells.
    Plan of Action: How the Spinal Cord Controls Movement
    Lectures
    Understanding the neural circuits in the spinal cord that control movement.
    Memories are Made of This
    Lectures
    The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice.
    From Venoms to Drugs
    Lectures
    Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
    Shedding Light on an Invisible World
    Lectures
    Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.
    Biodiversity at a Snail's Pace
    Lectures
    Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
    Eavesdropping on Tiny Conspiracies
    Lectures
    The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.
    Q&A on Quorum Sensing
    Lectures
    In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.
    Exploring Biodiversity: The Search for New Medicines
    Series
    What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
    How the Immune System Detects Invaders
    Lectures
    The immune system recognizes invaders in a complex way.
    Senses and Sensitivity: Neuronal Alliances for Sight and Sound
    Series
    In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.
    Cloning an Army of T Cells for Immune Defense
    Animation
    View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the...
    The LUX operon controls light production
    Animation
    A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.
    Motor cabal toxins block motor neuron synapses
    Animation
    Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.

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