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- (-) Remove 2002 - Genomics/Chemical Genetics filter2002 - Genomics/Chemical Genetics
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Click & Learn
How both gene chips and microarray slides are created.
Click & Learn
Small molecules are chemicals that can interact with proteins to affect their functions. Learn about the structure and biological functions of various small molecules like sugar and caffeine.
Click & Learn
DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.
Click & Learn
All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.
Classroom Resource
To accompany the lecture series Scanning Life's Matrix: Genes, Proteins, and Small Molecules.
Classroom Resource
A text transcript of the 2002 Holiday Lectures on Science, Scanning Life's Matrix: Genes, Proteins, and Small Molecules.
Classroom Resource
A chapter list to accompany the DVD.
Video Clips
Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS.
Interview
An interview with Manolis Kamvysselis, a scientist in Dr. Lander's lab.
Interview
An interview with Angela Koehler, a scientist in Dr. Schreiber's lab.
Video Clips
How a microarraying robot delivers hundreds of small molecules to a series of slides.
Lectures
Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.
Lectures
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Lectures
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Lectures
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
Lectures
A wide-ranging 45-minute discussion between Dr. Eric Lander, Dr. Stuart Schreiber, and four Washington DC-area high school teachers.
Series
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
Animation
One technique for discovering small molecules of biological relevance is to expose cultured cells to a variety of small molecules and look for changes in the cells' appearance, behavior or other measurable qualities.
Animation
The hypothetical relationship of chemical space and biological space is plotted on a three-dimensional graph, giving a glimpse of the future direction of research at the intersections of various disciplines.
Animation
In diversity-oriented synthesis, many combinations of chemical building blocks undergo relatively few reaction steps to form a vast variety of different molecules. In this example, 45 x 45 x 45 combinations yield more than 88,000 novel molecules.
Animation
The small molecule 'furrowstatin' exemplifies the power of using small molecules to investigate life's processes. When applied to dividing cells, the furrowstatin halts cell division.
Animation
Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.
Animation
After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.
