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Showing 1 - 25 of 42 results
Classroom Resource
Construct evolutionary trees by sorting seashells. To accompany the lecture series Exploring Biodiversity: The Search for New Medicines and the Sorting Seashells Click and Learn interactive.
Click & Learn
Explore principles of taxonomy by sorting seashells according to their morphological characteristics and constructing an evolutionary tree.
Interview
An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.
Interview
An interview with Dr. Audra Pompeani, a graduate student in Bonnie Bassler's lab.
Interview
An interview with Dr. Lee Swem, a post-doctoral fellow in Bonnie Bassler's lab.
Click & Learn
Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.
Click & Learn
Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.
Classroom Resource
A text transcript of the 2009 Holiday Lectures on Science, Exploring Biodiversity: The Search for New Medicines.
Classroom Resource
A chapter list to accompany the DVD.
Lectures
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Lectures
Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.
Lectures
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
Lectures
The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.
Lectures
A discussion on biodiversity, endangered habitats, and how best to preserve the Earth's ecosystems, presented by the lecturers along with Dr. E.O. Wilson and Dr. Eric Chivian.
Lectures
In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.
Lectures
In this ten-minute Q&A session, Dr. Olivera answers questions on cone snail behavior, venoms, and biodiversity.
Series
What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Animation
Some cone snail toxins chemically hyperactivate neurons and immobilize prey, much like a Taser.
Animation
A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.
Animation
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
Animation
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
Animation
Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.
Animation
Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.
