Howard Hughes Medical Institute 2010 Annual Report

William G. Kaelin

William G. Kaelin

Kaelin Wins Gairdner Award

William G. Kaelin, an HHMI investigator at Dana-Farber Cancer Institute, was one of five scientists awarded 2010 Canada Gairdner International Awards from the Gairdner Foundation. Each award carries a $100,000 cash prize. The annual Gairdner awards recognize leading medical researchers around the world. Kaelin shares his award with Peter J. Ratcliffe of the University of Oxford and Gregg L. Semenza of the Johns Hopkins University School of Medicine for their studies on how cells sense oxygen levels.

Thomas Südhof

Thomas Südhof

Thomas Südhof Awarded Kavli Prize in Neuroscience

The Norwegian Academy of Science and Letters named Thomas Südhof, an HHMI investigator at Stanford University School of Medicine, as one of eight recipients of 2010 Kavli Prizes. The eight scientists will share $3 million in prize money. Südhof shares the Kavli Prize in Neuroscience with Richard H. Scheller of Genentech and James E. Rothman of Yale University for their work on how neurons in the brain communicate with each other.

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Carolyn Bertozzi

Carolyn Bertozzi

Carolyn Bertozzi Awarded Lemelson-MIT Prize

Carloyn Bertozzi, an HHMI investigator at the University of California, Berkeley, won the 2010 Lemelson-MIT Prize. The prestigious $500,000 award recognizes an outstanding inventor or innovator each year. Bertozzi is the first woman to receive the prize, and among the youngest recipient.

Bertozzi studies sugar molecules, called glycans, that are vital to cellular pathways throughout the body. She aims to develop chemical and nanoscale tools to probe biological processes involving glycans. Her team invented the world’s first chemical reaction to add a marker to sugars or proteins, allowing researchers to trace their paths as the molecules move throughout an organism.

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Jeannie T. Lee

Jeannie T. Lee

Lee Wins National Academy Award

HHMI investigator Jeannie T. Lee, of Massachusetts General Hospital, won the 2010 National Academy of Sciences Award in Molecular Biology. Each year, the award recognizes a young scientist who has made a notable discovery. Lee was chosen for her research using X-chromosome inactivation as a system to study epigenetic regulation on a broader scale. She has found that genes responsible for X chromosome inactivation can also inactivate parts of other chromosomes.

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William T. Newsome

William T. Newsome

William Newsome Receives the Champalimaud Vision Award

HHMI investigator William T. Newsome, of Stanford University School of Medicine, received the 2010 Champalimaud Vision Award for his research on the neural circuits underlying vision and visually based decision making. The $1.3 million prize is given annually by the Champalimaud Foundation. In odd-numbered years it recognizes accomplishments in preventing blindness in developing countries, and in even-numbered years honors a scientist for outstanding vision research.

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Robert J. Lefkowitz

Robert J. Lefkowitz

Frontiers of Knowledge Award Goes to Lefkowitz

The BBVA Foundation selected Robert J. Lefkowitz, an HHMI investigator at Duke University, to receive the Frontiers of Knowledge Award in Biomedicine. This is the second year that the 400,000 euro prize has been given. Lefkowitz was honored for discovering G protein-coupled receptors, now the largest family of cell receptors known.

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Jeffrey M. Friedman

Jeffrey M. Friedman

Keio Prize Goes to Friedman

The 2009 Keio Science Prize was awarded to HHMI investigator Jeffrey M. Friedman in recognition of his research on hormones that regulate food intake and body weight. Friedman, of The Rockefeller University, studies leptin, a molecule linked to appetite and obesity. Friedman discovered, using techniques in neurobiology and genetics, that when an animal loses weight, leptin concentrations fall and this causes the animal to search for food. The Keio Prize carries a monetary value of 20 million yen (about $220,000) and is given annually by Keio University, in Japan, for outstanding research in medical science.

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Elaine Fuchs

Elaine Fuchs

Fuchs Wins Medal of Science and L’Oréal-UNESCO Award

Elaine Fuchs, an HHMI investigator at The Rockefeller University, received the National Medal of Science from President Barack Obama at a ceremony at the White House in October 2009. Eight other scientists were also presented medals—the nation’s highest honor for science.

Fuchs was honored for her research on skin and hair—two distinct structures that develop from the same skin stem cell. Her work has made inroads into understanding hair growth and how defective stem cells can cause cancer. Fuchs also is the North American recipient of the 2010 L’Oréal-UNESCO Award in the Life Sciences, which recognizes outstanding and inspirational women scientists from five regions around the globe each year. The $100,000 prizes are a result of a partnership between the cosmetics company L’Oréal and the United Nations Educational, Scientific, and Cultural Organization.

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Catherine Dulac Gerald I. Shulman
Shirleen Roeder Michael F. Summers
Michael G. Rosenfeld Christopher A. Walsh
John D. Scott Wayne Yokoyama
Andrey S. Shaw Utpal Banerjee
Charles J. Sherr Graham F. Hatfull
Cynthia Wolberger

Top row: Dulac, Roeder, Rosenfeld, Scott, Shaw, Sherr, Wolberger. Bottom row: Shulman, Summers, Walsh, Yokoyama, Banerjee, Hatfull.

13 HHMI Scientists Join American Association for the Advancement of Science

A total of 11 HHMI investigators and 2 HHMI professors were named fellows of the American Association for the Advancement of Science. The investigators are Catherine Dulac, Harvard University; G. Shirleen Roeder, Yale University; Michael G. Rosenfeld, University of California, San Diego; John D. Scott, University of Washington; Andrey S. Shaw, Washington University in St. Louis; Charles J. Sherr, St. Jude Children’s Research Hospital; Gerald I. Shulman, Yale School of Medicine; Michael F. Summers, University of Maryland, Baltimore County; Christopher A. Walsh, Children’s Hospital, Boston; Cynthia Wolberger, Johns Hopkins University School of Medicine; and Wayne Yokoyama, Washington University School of Medicine in St. Louis. The professors are Utpal Banerjee, University of California, Los Angeles, and Graham F. Hatfull, University of Pittsburgh.

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Kristi S. Anseth Tyler E. Jacks
Patrick O. Brown Michel C. Nussenzweig
Arul M. Chinnaiyan Amita Sehgal
Daniel A. Haber Bruce D. Walker

Top row: Anseth, Brown, Chinnaiyan, Haber. Bottom row: Jacks, Nussenzweig, Sehgal, Walker.

Eight HHMI investigators join the Institute of Medicine

A total of eight HHMI investigators were elected to the National Academy of Science’s Institute of Medicine in October 2009. Those newly elected are Kristi S. Anseth, University of Colorado, Boulder; Patrick O. Brown, Stanford University School of Medicine; Arul M. Chinnaiyan, University of Michigan; Daniel A. Haber, Massachusetts General Hospital; Tyler E. Jacks, Massachusetts Institute of Technology; Michel C. Nussenzweig, The Rockefeller University; Amita Sehgal, University of Pennsylvania School of Medicine; and Bruce D. Walker, Massachusetts General Hospital.

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Angelika Amon Douglas E. Koshland
Vann Bennett Ruslan M. Medzhitov
Nancy L. Craig Roeland Nusse
Don Ganem Charles L. Sawyers
Eric Gouaux Terrence J. Sejnowski
William G. Kaelin, Jr. Lynn M. Riddiford

Top row: Amon, Bennett, Craig, Ganem, Gouaux, Kaelin. Bottom row: Koshland, Medzhitov, Nusse, Sawyers, Sejnowski, Riddiford.

HHMI Scientists Elected to National Academy of Sciences

Eleven HHMI investigators and one Janelia Farm fellow were elected to the National Academy of Sciences in April 2010. They are Angelika Amon, Massachusetts Institute of Technology; Vann Bennett, Duke University; Nancy L. Craig, The Johns Hopkins University School of Medicine; Don Ganem, University of California, San Francisco; Eric Gouaux, Oregon Health & Science University; William G. Kaelin, Jr., Dana-Farber Cancer Institute; Douglas E. Koshland, Carnegie Institution of Washington; Ruslan M. Medzhitov, Yale School of Medicine; Roeland Nusse, Stanford University School of Medicine; Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center; and Terrence J. Sejnowski, Salk Institute for Biological Studies. The senior fellow at Janelia Farm Research Campus is Lynn M. Riddiford.

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Lasker Award Honors Long Road

Lasker Award Honors Long Road

Decades of deeply collaborative work led to a promising treatment for chronic myeloid leukemia.

No Question Too Big

No Question Too Big

For Jack Szostak, a Nobel is more than a prize; it also honors the spirit of enterprise that drives his work.

A Roadmap to the Ribosome

A Roadmap to the Ribosome

To resolve the ribosome’s structure, Nobel laureate Thomas A. Steitz needed the right equipment and an inventive research team.

Annual Reflections

Annual Reflections

HHMI President Robert Tjian’s annual letter, accompanied by reflections from Trustee Hanna H. Gray.

Photo Credit: Kaelin: Paul Fetters  Sudhof: Paul Fetters  Bertozzi: Courtesy of Carolyn Bertozzi  Lee: Courtesy of Jeannie Lee  Newsome: Brie Linkenhoker  Lefkowitz: Stewart Waller / PR Newswire, © HHMI  Friedman: Courtesy of The Rockefeller University  Fuchs: Courtesy of The Rockefeller University  Dulac: Matt Kalinowski  Roeder: Paul Fetters  Rosenfeld: Paul del Castillo Sabatini: Robert E. Klein/AP, HHMI  Scott: Lorene Langeberg  Shaw: Sarah Conard / PR Newswire, © HHMI  Sherr: Seth Dixon/St. Jude Hospital  Shulman: Courtesy of Yale University Summers: Tim Ford/UMBC  Walsh: Joshua Dalsimer  Wolberger: Courtesy of Cynthia Wolberger  Yokoyama: Paul Fetters  Banerjee: Joe Toreno  Hatfull: Annie O’Neill  Anseth: Carmel Zucker Brown: Paul Fetters  Chinnaiyan: Courtesy University of Michigan  Haber: Darren McCollester / PR Newswire, © HHMI  Jacks: Paul Fetters  Nussenzweig: Paul Fetters  Sehgal: Paul Fetters Walker: Steve Gilbert  Amon: Paul Fetters  Bennett: Jeffery McCullough  Craig: Paul Fetters  Ganem: Michael Armanini  Gouaux: Paul Fetters  Kaelin: Paul Fetters  Koshland: Courtesy of Douglas Koshland  Medzhitov: Chris Jones  Nusse: Paul Fetters  Sawyers: Liz Baylen / PR Newswire, © HHMI  Sejnowski: Paul Fetters  Riddiford: Paul Fetters