HomeAdvance ScienceEric Betzig – Career Detour? No Problem
Eric Betzig – Career Detour? No Problem

Eric Betzig’s career path has been anything but conventional. The physicist zigzagged through a variety of positions in academia and industry, ultimately landing among the original group of scientists who joined HHMI’s Janelia Farm Research Campus in 2005.

At Janelia, Betzig creates novel optical imaging tools for molecular, cellular, and neurobiology. A pioneer in developing near-field microscopy for ultra-high-resolution optical imaging, Betzig previously spent six years at AT&T’s Bell Laboratories. There, he was the first to image subcellular details beyond the so-called diffraction limit, which had hampered scientists’ ability to see details of proteins inside cells. Betzig and his colleagues were also the first to image single fluorescent molecules—a key methodology in modern biophysics.

Growing disillusioned with the near-field technique and academic science in general, he left Bell Labs and joined his father’s machine tool company in Michigan, where he spent seven years developing and then marketing a precise motion control technology for automated cutting tools. However, the technology was a commercial failure.

Unemployed, Betzig considered how best to return to scientific research without going back to work in a traditional academic lab. With his friend and colleague Harald Hess, Betzig later devised a simpler approach to optical imaging of cells at near-molecular resolution, termed photoactivated localization microscopy, or PALM. They paid for the R&D themselves and built the prototype in Hess’s living room in La Jolla, CA. Today, most commercial microscope manufacturers offer variants of PALM technology. Their work caught the attention of Janelia’s executive director Gerald Rubin, who recruited Betzig to Janelia.

In 2005, Betzig became one the first group leaders at Janelia, where he and his colleagues have since developed an array of powerful microscope technologies. One uses adaptive optics, a technology originally developed for telescopes but now applied to image the architecture and activity of neural connections in the brains of living mice. Another uses Bessel beams, ultrathin pencils of light similar to those used in supermarket barcode scanners, to rapidly image the complex three-dimensional dynamics within single living cells.

Image: Paul Fetters


About the Janelia Farm Research Campus:

HHMI created Janelia, a fully HHMI-funded research facility, to host leading scientists in pursuit of long-range research projects. The campus is designed to bring together researchers from disparate disciplines. Biologists work alongside computer scientists, engineers, physicists, and chemists in an environment free of the traditional disciplinary boundaries one might encounter in academia. Research teams are small, and team leaders are actively involved in research rather than just managing it. Read more >>